In addition, obesity is also linked to the increased endoplasmic reticulum stress and the activation of unfolded protein machinery, able to activate NF-κB, JNK, and induce a redox perturbation defined oxidative stress, that will further up-regulate inflammatory cytokines release (Maher Cnop et al., 2012). This evidence concerns the gene MAPK8 and obesity due to melanocortin 4 receptor deficiency.