This included the up-regulation of the gene for collagen VIII (Col8a1), and the down-regulation of the mineralocorticoid receptor Nr3c2. Potassium voltage-gate Kcna1 was highly down-regulated and has been previously associated with atrial fibrillation (Glasscock et al., 2015). The gene discussed is NR3C2; the disease is atrial fibrillation.