Moreover, the antidepressant-like effects of VBL water extract (VBLW) on the FST, the OFT, and the levels of monoamine neurotransmitters (e.g., serotonin, dopamine, and norepinephrine) and endogenous hormones (e.g., CRH, ACTH, and CORT) associated with the monoamine system and HPA axis in the brain (hippocampus and PFC) and serum in CRS-induced depression mice were studied. Here, POMC is linked to congenital rubella syndrome.