DAM downregulate homeostatic microglial genes such as P2ry12, Tmem119 and Cx3cr1, while inducing the expression of several AD associated activation markers, such as Apoe, Tyrobp and Trem2 (Keren-Shaul et al., 2017; Krasemann et al., 2017). Here, APOE is linked to Alzheimer disease.