GPI and Parkinson disease: Interestingly in PD where GPi activity is altered secondary to dopamine deficiency (Tremblay et al., 1989; Filion and Tremblay, 1991; Desikan et al., 2006; Wichmann and Soares, 2006; Moran et al., 2012; Devergnas et al., 2014), impairment of bimanual coordination (Johnson et al., 1998; Palmer et al., 2009) as well as movement lateralization (Cincotta et al., 2006; Wu et al., 2015) has been described.