The analyses both in our tumor collection (Fig. 2) and in the TCGA collection (Fig. S3) using Illumina HM450K arrays demonstrated that the 5′ region of the VWA2 CGI underwent negligible changes in methylation in CRC primary tumors, while the 3′ region of the CGI and, particularly, the south shore interrogated by probes cg22923514 (region 3) and cg10407585 (region 4) exhibited significant hypomethylation that correlates with transcriptional up-regulation (Fig. S4). Here, VWA2 is linked to neoplasm.