MYC and hepatocellular carcinoma: This data revealed a significant enrichment of c-myc at the E-box containing VWA2 DNA region in two cancer cell lines, MCF-7 (breast cancer) and HepG2 (hepatocellular carcinoma) and in the embryonic stem cells H1-hESC (Supplementary Fig. S7), supporting that c-myc can directly bind this DNA region in cells where MYC is highly expressed23.