In this work, we further explored that initial observation, we mapped the frequently altered NotI site within the intronic region 635 bp downstream of the canonical transcriptional start site (TSS) of VWA2 gene, and characterized in much higher detail the incidence, extension, and functional consequences of somatic DNA hypomethylation of VWA2 in both primary CRC samples and cell lines. Here, VWA2 is linked to colorectal carcinoma.