EBI3 and Anxiety: There were no significant differences among WT, WSX-1−/− (WSX-1-deficient), EBI3−/− [Epstein-Barr virus-induced gene 3 (EBI3)-deficient)], and p28−/− (p28-deficient) mice in any parameters obtained from the open field and rotarod tests, suggesting that IL-27/WSX-1 signalling-deficient mice did not have substantial dysfunctions in locomotor activity or anxiety-like behaviour (see Supplementary Fig. S1).