For instance, the inhibition of AKR1B10 significantly suppressed the tumor progress in gastrointestinal cancer, pancreatic cancer, breast cancer etc19–21, and over-expressed AKR1B10 induced cisplatin resistance enhancement by positively regulating peroxisome proliferator activated receptor-γ (PPARγ)6. The gene discussed is PPARG; the disease is pancreatic neoplasm.