Their resultssuggested, at least in part, that RNA transported in exosomes plays a role inbystander effects.44 A study by Zhang et al. found miR-1246 could beregulated by p53 in human hepatocellular carcinoma cell lines to suppress cellproliferation and colony formation ability.45 Serum exosomal miR-1246 wasshown to significantly inhibit prostate cancer cell growth and decreaseproliferation.46 However, contrasting studies have also suggesteddifferent roles of exosomal miR-1246 in bystander effects. The gene discussed is TP53; the disease is hepatocellular carcinoma.