A study by Yuan et al.suggested that miR-1246 functions as an oncogene-like RNA and could act as amessenger to promote cell proliferation and enhance radiotherapy resistance betweenirradiation targeted and nonirradiated bystander cells by directly targeting DR5 inlung cancer cells.47 Similarly, breast cancer cells treated withexosomal miR-1246 could also promote cell proliferation and enhance chemotherapyresistance of nonmalignant HMLE cells.48 The controversial roles regarding miR-1246 mightattribute to applying different tumour cell modes in those studies. Here, TNFRSF10B is linked to breast cancer.