Ten PCRCs had already acquired many non-silent mutations in known CRC driver genes18 such as APC, KRAS, PIK3CA, FBXW7, SMAD4, and TP53 (observed in 8, 7, 3, 1, 1, and 1 patients, respectively; Fig. 1). The gene discussed is TP53; the disease is colorectal carcinoma.