Interestingly, EMT-type CSCs (CD44+) are associated with low SIRT7 and share similar set of genes with OCT3/4, suggesting differential roles of Sirtuins on breast cancer stemness: SIRT1 is related to MET-type CSCs (ALDH1+), whereas SIRT7 is correlated with EMT-type (CD44+). This evidence concerns the gene SIRT1 and breast cancer.