Finally, since we observed a significant decrease of β-arrestin1 protein levels in thymocytes from N3-ICtg when compared to WT mice (Fig. 7f), which would further support its role in regulating CXCR4 expression, in order to investigate a possible translational significance of the correlation between the CXCR4 receptor and the β-arrestin1 adaptor/scaffold protein, we performed an in silico analysis of CXCR4 and β-arrestin1 gene expression in a cohort of 117 T-ALL pediatric patients [42]. The gene discussed is CXCR4; the disease is acute lymphoblastic leukemia.