NOTCH3 and acute lymphoblastic leukemia: We report here for the first time how a wave of “thymus-derived” Notch3+highCXCR4+highDP-cells is able to home and engraft into BM of NSG recipient mice, while the ability of “bone marrow-derived” leukemic cells to infiltrate lymphoid organs and CNS in T-ALL was previously reported [24, 25, 47].