Our experiments revealed increased ZDHHC8 expression in the neocortical tissue of TLE subjects, similar to that observed in the hippocampus and adjacent cortex of chronic seizure model mice, suggesting that in vivo regulation of ZDHHC8 is coupled to epileptic or pathogenic brain activity and that ZDHHC8 plays a role in human epilepsy. This evidence concerns the gene ZDHHC8 and epilepsy.