AKT1 and metastatic malignant neoplasm: Hyperactivation of the PI3K/AKT/mTOR (phosphatidylinositol-3-kinase/AKT/mammalian target of rapamycin) signaling pathway has been correlated to radioresistance and EMT in prostate cancer53 and chemoresistance in many different types of metastatic cancer such as breast cancer18,54,55 and CRC56.