Based on the recent study of altered lncRNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia [14], the metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was verified as one of the most up-regulated lncRNAs, which was involved in protecting BMECs from cerebral ischemic injury [15]. The gene discussed is MALAT1; the disease is brain ischemia.