POTEF-AS1 promotes PC cell lines (LNCaP and LTAD) growth by targeting TNFSF10 (the tumor necrosis factor superfamily member 10) which belongs to pro-apoptotic protein ligands of the tumor necrosis factor superfamily and TLR3 which triggers apoptosis and growth arrest of LNCaP cells partially through the inactivation of the PI3K/Akt signaling pathway [39]. Here, AKT1 is linked to pachyonychia congenita.