For instance, over-expression of SOCS2-AS1(The lncRNA Suppressor of cytokine signalling 2-antisense transcript 1) enhanced proliferation and migration of PC cells and it inhibits PC cells apoptosis by down regulating the expression of TNFSF10, particularly in castration-resistant cell lines [50, 63]. This evidence concerns the gene SOCS2 and pachyonychia congenita.