YAP1 and neoplasm: Given that RASAL2 abrogated the tumor suppressor function of LATS2, we conducted rescue experiment in which we co-transfected siLATS2, siRASAL2 or both into SW620 (KRAS G12 V) and Caco2 (KRAS/NRAS wild-type) cells and evaluated the effect on phospho-YAP1(S127) expression.