RASAL2 and neoplasm: Upregulation of RASAL2 mRNA in CRC was validated independently in the Hong Kong local cohort (P < 0.01), Gene Expression across Normal and Tumor tissue (GENT) [26] (GSE20916 [27], P < 0.01 and GSE21510 [28], P < 0.01) and The Cancer Genome Atlas (TCGA) [29, 30] (P < 0.05) (Fig. 1c).