In 2011, Kaminski and colleagues reported the existence of a correlation between hemostatic factors such as tissue factor, von Willebrand factor, thrombomodulin, soluble urokinase-type plasminogen activator receptor, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion protein and the fraction of IS in CKD patients not undergoing hemodialysis [60]. Here, VWF is linked to chronic kidney disease.