In current research, we found that, during the influenza virus FM147 infection, the ORNs-d-M efficiently impair activation of Toll-like receptors (TLR) 3, 7, 8 signaling pathways, interfere up-expression of TLRs (tlr3, tlr7, tlr8), nuclear factor NF-kB (nfkbia, nfnb1), cytokines (ifnε, ifnk, ifna2, ifnb1, ifnγ, il6, il1b, il12a, tnf), chemokines (ccl3, ccl4, сcl5, cxcl9, cxcl10, cxcl11), interferon-stimulated genes (ISGs) (oas1a, oas2, oas3, mx1), and pro-oxidation (nos2, xdh) genes that induced the infection. This evidence concerns the gene OAS3 and infection.