Therefore, we studied the influence of the ORNs-d-М on up-expression of the cytokines, chemokines, and ISGs-induced influenza virus and found that impairing overexpression of ifnε, ifnk, ifna2, ifnb1, ifnγ, oas1a, oas2, oas3, mx1, il6, il1b, il12a, tnf, ccl3, ccl4, сcl5, cxcl9, cxcl10, and cxcl11 induced influenza virus infection through the ORNs-d-М that had been injected into mice for prevention and treatment of this infection. The gene discussed is TNF; the disease is infection.