TNF and metabolic dysfunction-associated steatohepatitis: In a recently described stroke-prone, spontaneously hypersensitive SHRSP5/Dmcr rat model, the pro-inflammatory TNFα cytokine and p50/p65 nuclear factor kappa B (NFkB) pathway mediated inflammatory signals and oxidative stress characteristic of the hepatic fibrotic and inflammatory status of NASH [21] when fed a diet rich in cholesterol.