Significantly, we reported that bacopaside II blocked the aquaporin-1 (AQP1) water channel and impaired the in vitro migration of HT-29 colon cancer cells that express comparatively high levels of AQP1, at concentrations that were not appreciably cytotoxic, but had minimal effect on migration of SW480, which expressed lower levels [12]. Here, AQP1 is linked to malignant colon neoplasm.