Several recent studies have established this link between hypoxia, myocardial ischemia, and iron metabolism: Isoda et al. showed that levels of iron-regulating hormone hepcidin, which strongly correlate with ferritin levels, show an abrupt increase of more than 100-fold in human cardiomyocytes within one day after myocardial infarction [21]. This evidence concerns the gene HAMP and myocardial ischemia.