Remarkably, this association remained significant (HR 1.73 (95% CI 1.07– 2.81; p = 0.026)) after an additional adjustment for surrogates of systolic heart function (NT-proBNP), for the size of myocardial necrosis (troponin I), and for anemia (hemoglobin). The gene discussed is NPPB; the disease is Myocardial necrosis.