Acylated ghrelin is able to bind to and activate the GHSR1a leading to, among other effects, a stimulation of food intake [8], reduction of insulin secretion resulting in hyperglycemia [9] and stimulation of gastric motility [10], whereas desacyl ghrelin—long thought to represent a non-active form of ghrelin—is assumed to counterbalance the orexigenic effect of acyl ghrelin [11,12]. The gene discussed is GHRL; the disease is Hyperglycemia.