TYR and melanoma: Two detoxified recombinant dCyaA proteins, each carrying a single copy of two human melanoma epitopes that associate with the HLA-A*02 haplotype, derived from tyrosinase or N-acetylglucosaminyltransferase V, respectively, were shown to induce potent epitope-specific CTL responses in transgenic mice expressing HLA-A*02 molecules [109].