TNF and neoplasm: In particular, in splenocytes and/or lymph nodes, we have observed an increased expression of mRNA of Th2 signature cytokines [43], such as Il4, Il5, Il9, or Il13. However, in splenocytes alone, calcitriol increased the level of Tnf, Il12b, and Il12rb2 at an early stage of tumor progression and decreased their levels during the advanced phase of the experiment.