According to the study by Spenser et al., where 4390 pregnant women were involved, the sensitivity of preeclampsia increased from 50% to 62% (with FPR of 5%) when a combination of decreased PAPP-A in the first trimester and increased uterine artery PI at 22–24 weeks of gestation were present [24]. The gene discussed is PAPPA; the disease is preeclampsia.