The effective prediction of preeclampsia can be achieved with an initial assessment at 11–13 weeks of gestation with the combination of maternal characteristics, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), maternal serum placental growth factor (PlGF), and pregnancy-associated plasma protein-A (PAPP-A) [6,7,8]. The gene discussed is PAPPA; the disease is preeclampsia.