CASP8 and endometriosis: A recent meta-analysis showed a remarkable consistency in endometriosis GWA results across studies, with little evidence of population-based heterogeneity.26 It also recommended functional studies in relevant tissues to understand the effect of the variants on downstream biological pathways.26 An interesting finding common to these three researches17, 18, 20 was the identification of the polymorphisms associated with endometriosis in chromosome 2, in which the CASP8 gene, investigated in the present study, is located.