Pathway analysis identified several signaling pathways implicated in chondrocyte function, such as Wingless and Int-1 (Wnt) signaling and insulin-like growth factor (Igf) signaling in the proliferative zone as well as basal cell carcinoma signaling (involving hedgehog signaling) in the hypertrophic zone (Fig 4A, S9 Table and S10 Table). This evidence concerns the gene IGF1 and basal cell carcinoma.