Moreover, we determined the basophil activation and in vivo‐sensitizing capabilities of allergen‐specific VNP, taking advantage of a recently established, human‐relevant TCR/DR1 transgenic mouse model.35 These transgenic mice express a human Art v 125‐36‐specific αβTCR and HLA‐DR1 and show hallmarks of allergic disease such as lung inflammation, airway hyper‐responsiveness (AHR), and allergen‐specific IgE upon natural i.n. exposure of mucosal surfaces to aqueous allergen extract in the absence of systemic priming or adjuvants. This evidence concerns the gene IGHE and allergic disease.