CEP57 and mosaic variegated aneuploidy syndrome 1: A TALEN-mediated knock-in strategy was used to generate a mouse model for the CEP57 c.915_925dup11 duplication mutation (hereafter referred to as Cep57T) that is frequently found in CEP57 MVA syndrome patients and truncates the protein (ref. 6, Figure 1A, and Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI120316DS1).