Importantly, we analysed the gene expression of class I HDACs in Hep3B cells cultured with CM from differentiated SGBS cells and found that this increased the expression of the class I HDACs HDAC 1, 2 and 8 suggesting that differentiated adipocytes may manipulate specific HDAC expression rather than global HDAC activity in liver cancer. The gene discussed is HDAC9; the disease is liver cancer.