Nguyen-Them et al. [87] reported that IL-10 CSF concentration can distinguish PCNSL from other neurologic diseases with sensitivity of 88.6% and specificity of 88.9% with a cut-off of 4 pg/ml, while Song et al. [88] reported diagnostic sensitivity and specificity of 95.5% and 96.1%, respectively, when IL-10 levels cut-off was set at 8.2 pg/ml. Here, IL10 is linked to nervous system disorder.