STAT3 and neoplasm: Different molecular mechanisms may also underlie these effects: (1) B7H3 induced the migratory potential and invasiveness of tumor cells by increasing the expression of metastasis-associated proteins such as MMP2, STAT3 and IL-8 (50); (2) by increasing the levels of CXCR4 and activating AKT, ERK, and JAK2/STAT3 pathways (52); (3) through activating the JAK2/STAT3/MMP9 pathway (55); (4) by increasing the expression of MMP2 (56); (5) by activating the TLR4/NF-κB signaling and increased IL-8 and VEGF expression (57).