Promotes cancer cell migration and invasion (33, 34)Counteracts pro-apoptotic effects of TGF-β1 through PI3K–Akt pathway (35)Linked to anchorage-independent growth observed in soft agar (35, 36)Potentiates cancer stem cell like properties through the activation of the hedgehog signaling pathway (22). The gene discussed is TGFB1; the disease is cancer.