The results of a recent phase III trial of osimertinib in comparison with gefitinib in previously untreated patients with EGFR mutation–positive advanced NSCLC suggest the possibility that osimertinib may be a treatment option for chemonaïve patients with EGFR-mutated NSCLC and Trousseau syndrome [12]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.