This is especially true for breast cancer, where the CDK4/6 inhibitors Palbociclib/Ibrance (Pfizer), Ribociclib/Kisqali (Novartis & Astex) and Abemaciclib/Verzenio (Eli Lilly) were recently licensed for use in combination with hormonal-based therapies for the management of ER+/HER2-advanced metastatic breast cancers due to the significant progression-free survival benefits it offers these patients [6–8]. This evidence concerns the gene ERBB2 and breast cancer.