CDK18 and neoplasm: However, in contrast to these findings, analysis of combined EGA and TCGA breast cancer samples (KM Plotter) suggests that high (above median) rather than low levels of CDK18 mRNA expression are associated with better patient survival (n = 3951, Log Rank P = 4.1e–8; Figure 1D), with a similar trend for ER- tumours (n = 801, HR = 0.81, Log Rank P = 0.075; Figure 1E), but not ER+ tumours (n = 2061, HR = 1, Log Rank P = 0.98; data not shown).