Genes mutated in 2 out of the 20 tumors were Atp5g3, Cdh7, Dennd2a, Esco2, Fndc3a, Gm1995, Gopc, Grb10, Mdc1, Nop58, Polr3c, Senp6, Serpinb3a, Serpinb3b, Serpinb3d, Spice1, Stxbp3a, Xylt2, and Zzef1. All other genes were found mutated in a single tumor and included known drivers of hepatocarcinogenesis such as Birc6, Hras, and Kmt2a. The gene discussed is SPICE1; the disease is neoplasm.