In turn, forced membrane expression of E-cad in the (E-cad non-expressing) mesenchymal breast cancer cell line, MDA-MB-231, significantly attenuates atorvastatin's growth inhibition [27], while inhibition of E-cad driven PI3K signaling through Akt potentiates the same cell line's statin sensitivity [37]. This evidence concerns the gene AKT1 and breast carcinoma.