OPTN and amyotrophic lateral sclerosis: In approximately 10% of ALS patients, the disease is inherited and caused by gene mutations, including mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP43), C9orf72, Optineurin (OPTN), P62 (Sequestosome 1, SQSTM1), Ubiquilin 2 (UBQLN2), TANK-binding kinase 1 (TBK1), and fused in sarcoma (FUS).