FOXO3 and amyotrophic lateral sclerosis: Dobrowolny et al. demonstrated that muscle atrophy was induced by FOXO3 induction and upregulation of autophagic pathway proteins, including microtubule-associated protein 1A/1B-light chain 3 (LC3), BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), and cathepsin L, in ALS animal models [7].