In addition, in kidney biopsies from patients with lupus nephritis (LN), there was evidence of TLR3, TLR7, and TLR9 overexpression with a positive correlation between TLR9 expression and high activity, measured by renal-systemic lupus erythematosus (R-SLEDAI) (80). The gene discussed is TLR9; the disease is systemic lupus erythematosus.