As Fcγ receptors (FcγR) is the immunoglobulin superfamily that contributes to the protective functions, in part, by inducing phagocytosis of opsonized microbes, loss of the inhibitory FcγR results in effective organism control but enhances the risk of autoimmune diseases (Ravetch and Bolland, 2001). Here, FCGR2A is linked to autoimmune disease.