FCGR2B and systemic lupus erythematosus: We examined macrophage functions, in vitro, as a pilot experiment because (i) the influence of macrophage against HP in lupus and wild-type might be different, (ii) the possible effect of high circulating immune complex against macrophage functions (Bolland and Ravetch, 2000; Clatworthy et al., 2007; Surawut et al., 2017) and (iii) the lack of data on FcγRIIb-/- macrophage against HP.