In addition, there was prominent immunoglobulin deposition in the glomeruli of FcγRIIb-/- mice (Figure 4) with the enhanced severity of lupus nephritis as demonstrated with serum creatinine, urine protein (urine protein creatinine index; UPCI), renal histology and serum cytokines (IL-6, MIP-2 and KC; the representatives of systemic inflammatory responses) (Figures 3C–H, 5). The gene discussed is CALCA; the disease is lupus nephritis.