FCGR2B and systemic lupus erythematosus: It is well known that chronic infection and inflammation initiates and accelerates lupus (Munoz et al., 2010; Esposito et al., 2014; Podolska et al., 2015; Rigante and Esposito, 2015) and the hyper-inflammatory responses in FcγRIIb-/- mice due to the inhibitory signaling defect (Clatworthy et al., 2007) might enhance this effect.