Interestingly, as CVD is a major risk for both type 2 diabetes and the metabolic syndrome, the association of HMGA1 rs139876191 variant with acute myocardial infarction, independently from diabetes and other cardiovascular risk factors, has been reported previously (147, 148), suggesting that HMGA1 may also represent a novel genetic marker of cardiovascular risk. This evidence concerns the gene HMGA1 and type 2 diabetes mellitus.