Indeed, transgenic mice, overexpressing HMGA1 in both white and brown adipose tissues, showed reduced fat mass and impaired adipogenesis with respect to wild-type mice (63), and were protected against high-fat diet induced obesity and systemic insulin resistance, thus supporting the role of HMGA1 in the maintenance of glucose homeostasis. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.