The mechanistic linkage between HMGA1, insulin resistance and certain less common forms of type 2 diabetes has been further supported by a study in two diabetic patients, in whom aberrant expression of a pseudogene for HMGA1, HMGA1-p, caused destabilization of HMGA1 mRNA with consequent loss of INSR and generation of insulin resistance (44). The gene discussed is HMGA1; the disease is type 2 diabetes mellitus.