Three variant were found in SCN1A, including two patients with Dravet syndromes (p.Leu890Pro, p.Arg1636Ter) and one family with genetic epilepsy with febrile seizure plus (GEFS+) (p.Met1714Val, Figure 1). Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.