RIPK3 and myocardial infarction: In conclusion, RIP3 mediates inflammation, ROS generation and adverse remodeling and RIP1 is critically involved in the pathophysiology of myocardial infarction, so the necroptosis pathway can be regarded as a therapeutic target for the improvement of left ventricular recovery and the reduction of myocardial infarct size after myocardial infarction.