Several of the likely mechanisms of action for a DA-driven facilitation of stroke recovery could be particularly associated with D1-class dopaminergic receptors, including the modulation of motor learning, augmentation of BDNF and GDNF levels and increase in cerebral blood flow and neurovascular coupling (Luft et al., 2004; Choi et al., 2006; Nitsche et al., 2009; Tan, 2009; Perreault et al., 2012; Xing et al., 2012; Kuric et al., 2013). This evidence concerns the gene GDNF and stroke disorder.