In addition to being a neuroprotective agent in stroke, FGF-2 (a.k.a. basic fibroblast growth factor) can act as an angiogenic factor to promote sprouting and neurogenesis in stroke models (Lin and Finklestein, 1997; Wada et al., 2003; Issa et al., 2005; Slevin et al., 2006; Paciaroni and Bogousslavsky, 2011). This evidence concerns the gene FGF2 and Stroke.