Previous works show that Lgi1 inhibits the proliferation and causes the apoptosis of neuroblastoma cells (Kunapuli et al., 2003; Gabellini et al., 2006), which might be mediated by altered AKT and ERK (extracellular-signal-regulated kinase) signaling (Kunapuli et al., 2003; Sirerol-Piquer et al., 2006) However, the roles of Lgi1 in oncogenesis still remain quite unclear. The gene discussed is LGI1; the disease is neuroblastoma.