Considering the mechanisms that regulate the proliferation of cancer cells, the key roles of the early responsive kinases, MAPKs (ERK, JNK, and p38 MAPK) and PI3K-AKTs have been well established (Chambard et al., 2007[3]; Chang et al., 2003[4]; Vadlakonda et al., 2013[29]). Here, MAPK8 is linked to cancer.