ANGPTL3 is a secreted protein, and previous studies have focused on its role in relation to target receptors on the cell membrane through the endocrine or paracrine pathway.44,45 However, we found that a considerable amount of the ANGPTL3 protein synthesised by RCC cells is still distributed inside these cells and can play a corresponding physiological role. Here, ANGPTL3 is linked to renal cell carcinoma.