FOXP3 and cancer: Ogiya et al. reported no changesin FOXP3+ T-cells, but significantly decreased CD8+ andCD4+ T-cells.30 Cimino-Mathews et al. reported that CD8+ and FOXP3+ T-cellssignificantly decreased.29 It is speculated that immune escape occurs with decreases in both theconcentrations of CD8+ T-cells (which suppress cancer proliferation) and lymphocytes(which promote cancer proliferation); this may imply an overall decrease in thefunctioning of the immune system.