Further polymorphisms associated with severe malaria were noted for rs1541255 in ATP2B4 (adjusted OR 0·76, 95% CI 0·63–0·92; p=0·001) and rs186873296 located in an intergenic region between FREM3 and GYPE (0·64, 0·53–0·79; p=3·18 × 10−14). This evidence concerns the gene FREM3 and malaria.