INPP4B and malaria: This finding supports the conclusion that the statistical association between severe malaria risk and SNPs in both FREM3—a gene of unknown biological relevance—and INPP4B are not in themselves causal with respect to malaria susceptibility but rather their associations might be accounted for by their close linkage disequilibrium with Dantu, which could most plausibly provide a malaria-protective mechanism on the basis of biological theory.